Lung Institute

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Publications 2007–2002

Pai M, Dheda K, Cunningham J, O’Brien R. T Cell Assays for the Diagnosis of Latent Tuberculosis Infection: Moving the Research Agenda Forward. Lancet Infect Dis. May 2007 (IF = 10.5).

Dheda K, Pooran A, Pai M, Miller RF, Lesley K, Booth HL, Scott GM, Akbar AN, Zumla A, Rook GA. Interpretation of Mycobacterium tuberculosis antigen-specific IFN-gamma release assays (T-SPOT.TB) and factors that may modulate test results.
J Infect. 2007 Apr 18; [Epub ahead of print].

Pai M, Mohan A, Dheda K, Leung CC, Yew WW, Christopher, DJ, Sharma, SK. Lethal interaction: the colliding epidemics of tobacco and tuberculosis. Expert Rev Anti Inf Ther; 5(3); 2007.

Lala S, Dheda K (co-1st authors), Chang J-S, Huggett JF, Kim LU, Johnson MA, Rook GAW, Keshav SA, Zumla A. The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis, BMC Infectious Diseases, 2007, 16;7:96.

van Zyl-Smit RN, Burch VC, Willcox P. The need for appropriate critical care service provision at non-tertiary hospitals in South Africa. S Afr Med J 2007;97(4) 268-272

van Zyl-Smit RN, Raine R. Acute Exacerbation of Obstructive lung Disease-Asthma or COPD does it matter?(Abstract) S Afr Resp J 2007;13(1) 29

Rook GA, Dheda K, Zumla A. Immune systems in developed and developing countries; implications for the design of vaccines that will work where BCG does not. Tuberculosis (Edinb) 2006 May-Jul;86(3-4):152-62. Epub 2006 Feb 28. (leading tuberculosis journal; IF= 3.8).

Chang JS, Huggett JF, Dheda K, Kim LU, Zumla A, Rook GA. Myobacterium tuberculosis Induces Selective Up-Regulation of TLRs in the Mononuclear Leukocytes of Patients with Active Pulmonary Tuberculosis. J Immunol 2006; 176(5):3010-8. (highly ranked immunology journal; IF= 6.8).

Pai M, Joshi R, Dogra S, Mendiratta DK, Narang P, Dheda K, Kalantri S. Persistently elevated T cell interferon-gamma responses after treatment for latent tuberculosis infection among health care workers in India: a preliminary report. J Occup Med Toxicol. 2006 May 23;1(1):7 [Epub ahead of print].

Pai M, Kalantri S, Dheda K. New tools and emerging technologies for the diagnosis of tuberculosis: part II. Active tuberculosis and drug resistance. Expert Rev Mol Diagn. 2006 May;6(3):423-32.

Pai M, Kalantri S, Dheda K. New tools and emerging technologies for the diagnosis of tuberculosis: part I. Latent tuberculosis. Expert Rev Mol Diagn. 2006 May;6(3):413-22.

Dheda K, Chang JS, Huggett JF, Kim LU, Johnson MA, Zumla A and Rook GAW. The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4δ2, is not. Tuberculosis (Edinb); Dec 29; Epub ahead of print. (leading tuberculosis journal; IF= 3.8).

Rook G, Dheda K, Zumla A. Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting? Vaccine 2005; 18;23(17-18):2115-20. (IF= 3.0).

Huggett JF, Dheda K, Bustin SA, Zumla A. Normalising mRNA levels in real-time PCR, an intractable problem, Genes & Imm 2005; 6(4):279-84. (IF = 3.8).

Dheda K, Udwadia ZF, Huggett JF, Johnson MA, Rook GAW. Utility of the antigen specific inteferon-gamma assay for the management of tuberculosis. Current Op in Pulm Med. 2005; 11(3):195-202. (IF = 2.1)

Dheda K, Chang JS, Kim LU, Huggett JF, Johnson MA, Zumla A, Rook GAW. Interpretation of the antigen specific Tuberculosis IFN-γ assay (letter). Lancet Inf Dis 2005; 5(6):324-5.

Dheda K, Chang JS, Breen RA, Kim LU, Haddock JA, Huggett JF, Johnson MA, Rook GAW, Zumla A. In vivo and in vitro studies of a novel cytokine, Interleukin-4delta2, in Pulmonary Tuberculosis. Am J Resp Crit Care Med 2005; 172(4):501-8. (leading respiratory journal; IF= 8.7).

Dheda K, Chang JS, Breen RA, Haddock JA, Huggett JF, Lipman MC, Johnson MA, Rook GAW, Zumla A. Expression of a novel cytokine, IL-4delta2, in HIV and HIV-Tuberculosis co-infection. AIDS 2005; 19(15):1601-1606. (leading HIV journal; IF = 5.8).

Dheda K, Chang JS, Huggett JF, Bustin SA, Johnson MA, Rook GAW, Zumla A. Comparison of validated and unvalidated reference gene for normalisation of real-time RT-PCR assays. Analytical Biochem 2005; 344(1):141-3. (IF = 2.7).

Rook GAW, Dheda K, Zumla A. Immune responses to TB in developing countries: implications for new vaccines. Nature Reviews Imm 2005; 5(8):661-7. (IF = 30.4).

Dheda K, Booth H, Huggett JF, Zumla A, Rook GAW. Lung remodelling in tuberculosis. J Infect Dis 2005; 192(7):1201-1209.
(IF ~ 5.0).

Dheda K, Lampe F, Lipman MC, Johnson MA, Rook GA. IRIS in mycobacterial infections; reply to Lu et al (letter). J Infect Dis. 2005;192(9):1674-5.

Dheda K, Lalvani A, Miller RF, Scott G, Booth H, Johnson MA, Zumla A, Rook GA. Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count. AIDS. 2005; 9(17):2038-2041. (IF = 5.8).

Davies PDO, Yew WW, Ganguly D, Davidow AL, Reichman LB, Dheda K, Rooke GAW. Smoking and Tuberculosis: The Epidemiological Association and Immuno-pathogenesis. Transactions of the Royal Soc Trop Med Hyg 2005; 100(4):291-8.

van Zyl-Smit RN, Burch VC, Willcox P. The Role of a Medical High Care Unit in service provision at an urban secondary level hospital in Cape Town.(Abstract) Southern African J of Critical Care, 2005;
21(1) 63

Dheda K, Cassim B, Patel N, Mody GM. A comparison of bone mineral density in Indians with psoriatic polyarthritis and healthy Indian volunteers. Clin Rheum 2004; 23:89.

Dheda K, Cassim B, Lalloo UG, Mody GM. Azathioprine for chronic interstitial lung disease associated with systemic sclerosis. Clin Rheum 2004;23(4):306-9.

Dheda K, Crawford A, Hagan G, Roberts CM. Implementation of British Thoracic Society guidelines for acute exacerbation of chronic obstructive pulmonary disease: impact on quality of life. Postgrad Med J. 2004 Mar;80:169-71

Dheda K, Roberts CM, Partridge MR, Mootoosamy I. Is Virtual Bronchoscopy useful for Physicians practicing in a District General Hospital? Postgrad Med J, 2004 ;80(945): 420-3.
Douse J, Derrett-Smith E, Dheda K, Dilworth JP. Should doctors wear white coats? Postgrad Med J. 2004;80:284-6.

Dheda K, Huggett JF, Kim LU, Zumla A. Type 2 cytokines in respiratory syncytial virus bronchiolitis (letter). Am J Respir Crit Care Med. 2004;169:1167-8.

Dheda K, Lampe FC, Johnson MA, Lipman MC. Outcome of HIV-associated tuberculosis in the era of highly active antiretroviral therapy (HAART). J Infect Dis, 2004;190:1670-6. (IF ~ 5.0; cited 20 times since publication; commentary in Journal Watch, Infectious Diseases and AIDS Care).

Dheda K, Huggett JF, Bustin SA, Johnson MA, Rook G, Zumla A. Study of reference gene expression in pulmonary tuberculosis using Real-Time PCR. Biotechniques, 2004;37(1):112-4. (leading biotechnology journal; cited 58 times since publication)

Dheda K, Rook G, Zumla A Peripheral T Cell Interferon-γ Responses and Latent Tuberculosis (letter). Am J Respir Crit Care Med, 2004; 170(1):97-8.

Rook G, Hernandez-Pando R, Dheda K, Seah GT. IL-4 in tuberculosis; implications for vaccine design. Trends in Immunology, 2004; 25(9):483-8. (IF = 10.1)

Dheda K, Johnson MA, Zumla A, Rook GA. Smoking is not beneficial for tuberculosis (letter). Am J Respir Crit Care Med. 2004;170(7):821.

Dheda K, Lim K, Ollivere B, Leftley J, Lampe FC, Salisbury A, Dilworth JP, Rajakulasingum R. Assessments for Oxygen Therapy in COPD: Are we under correcting arterial oxygen tensions? Eur Resp J 2004; 24(6):954-7. (IF= 3.95).

Huggett JF, Dheda K, Rook G, Zumla A. Mycobacterium paratuberculosis and Crohns Disease (letter). Lancet 2004; 364:2178.

Baird R, van Zyl-Smit RN, Iveson A, Duddy J, Rassam S. Thalidomide is highly effective in a patient with acute myeloid leukaemia. Leukaemia and Lymphoma 2004 Jan;45(1):179-81

Baird R, van Zyl-Smit RN, Dilke T, Scott S, Rassam S. Spontaneous remission of low-grade B-cell non-Hodgkin’s Lymphoma following withdrawal of methotrexate in a patient with Rheumatoid arthritis British Journal of Haematology 2002 118 567-568

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