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Publications
The immunology of tuberculosis: from bench to bedside.
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y.
Respirology. 2010 Apr;15(3):433-50.
PMID: 20415982 |
Cerebrospinal T Cell Responses Aid the Diagnosis of Tuberculous Meningitis in a HIV and TB Endemic Population.
Patel VB, Singh R, Connolly C, Coovadia Y, Peer AK, Parag P, Kasprowicz V, Zumla A, Ndung'u T, Dheda K.
Am J Respir Crit Care Med. 2010 May 4. [Epub ahead of print]
PMID: 20442433 |
Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum.
Cashmore TJ, Peter JG, van Zyl-Smit RN, Semple PL, Maredza A, Meldau R, Zumla A, Nurse B, Dheda K.
PLoS One. 2010 Apr 28;5(4):e10389.
PMID: 20442850 |
World TB Day 2010: eradicating tuberculosis in sub-Saharan Africa needs effective and committed north-south partnerships.
Marais B, Hoelscher M, Mwaba P, Dheda K, Zumla A.
S Afr Med J. 2010 Mar 8;100(3):153-4. No abstract available.
PMID: 20459935 |
Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis.
Gandhi NR, Nunn P, Dheda K, Schaaf HS, Zignol M, van Soolingen D, Jensen P, Bayona J.
Lancet. 2010 May 22;375(9728):1830-43.
PMID: 20488523 |
Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study.
Dheda K, Shean K, Zumla A, Badri M, Streicher EM, Page-Shipp L, Willcox P, John MA, Reubenson G, Govindasamy D, Wong M, Padanilam X, Dziwiecki A, van Helden PD, Siwendu S, Jarand J, Menezes CN, Burns A, Victor T, Warren R, Grobusch MP, van der Walt M, Kvasnovsky C.
Lancet. 2010 May 22;375(9728):1798-807.
PMID: 20488525 |
Review of multidrug-resistant and extensively drug-resistant TB: global perspectives with a focus on sub-Saharan Africa.
Migliori GB, Dheda K, Centis R, Mwaba P, Bates M, O'Grady J, Hoelscher M, Zumla A.
Trop Med Int Health. 2010 Jun 10. [Epub ahead of print]
PMID: 20545927 |
Tuberculosis research update.
Hanekom WA, Lawn SD, Dheda K, Whitelaw A.
Trop Med Int Health. 2010 Jun 15. [Epub ahead of print]
PMID: 20561306 |
| Peter J, Green C, Hoelscher M, Mwaba P, Zumla A, Dheda K. Urine for the diagnosis of tuberculosis: current approaches, clinical applicability, and new developments. Curr Opin Pulm Med. 2010 May;16(3):262-70. PubMed PMID: 20375787. |
Dheda K, Davids V, Lenders L, Roberts T, Meldau R, Ling D, Brunet L, van Zyl Smit R, Peter J, Green C, Badri M, Sechi L, Sharma S, Hoelscher M, Dawson R, Whitelaw A, Blackburn J, Pai M, Zumla A. Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples. PLoS One. 2010 Mar 24;5(3):e9848. PubMed PMID: 20352098; PubMed Central
PMCID: PMC2844421. |
| Zumla A, Huggett J, Dheda K, Green C, Kapata N, Mwaba P. Trials and tribulations of an African-led research and capacity development programme: the case for EDCTP investments. Trop Med Int Health. 2010 Feb 17. [Epub ahead of print] PubMed PMID: 20180932. |
| Pooran A, Booth H, Miller RF, Scott G, Badri M, Huggett JF, Rook G, Zumla A, Dheda K. Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis. BMC Pulm Med. 2010 Feb 22;10:7. PubMed PMID: 20170555; PubMed Central PMCID: PMC2837635. |
Lenders LM, Meldau R, van Zyl-Smit RN, Woodburne V, Maredza A, Cashmore TJ,
Semple PL, Badri M, Zumla A, Dheda K. Comparison of same day versus delayed
enumeration of TB-specific T cell responses. J Infect. 2010 Feb 10. [Epub ahead
of print] PubMed PMID: 20152856. |
| van Zyl-Smit R, Meldau R, Dheda K. Quantitative pulmonary T-cell responses for
the diagnosis of active tuberculosis. Am J Respir Crit Care Med. 2010 Feb
1;181(3):289; author reply 289-90. PubMed PMID: 20093656. |
Grange J, Adhikari M, Ahmed Y, Mwaba P, Dheda K, Hoelscher M, Zumla A.
Tuberculosis in association with HIV/AIDS emerges as a major nonobstetric cause
of maternal mortality in Sub-Saharan Africa. Int J Gynaecol Obstet. 2010
Mar;108(3):181-3. Epub 2010 Jan 13. PubMed PMID: 20070964. |
| Grange J, Mwaba P, Dheda K, Höelscher M, Zumla A. World TB Day 2010 - New
innovations are required for enhancing the global fight against Tuberculosis: the
'Captain of all these men of death'. Trop Med Int Health. 2010 Jan 11. [Epub
ahead of print] PubMed PMID: 20070628. |
| van Zyl Smit RN, Pai M, Yew WW, Leung CC, Zumla A, Bateman ED, Dheda K. Global
lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and
COPD. Eur Respir J. 2010 Jan;35(1):27-33. Review. PubMed PMID: 20044459. |
| van Zyl-Smit RN, Zwerling A, Dheda K, Pai M. Within-subject variability of
interferon-g assay results for tuberculosis and boosting effect of tuberculin
skin testing: a systematic review. PLoS One. 2009 Dec 30;4(12):e8517. Review. |
| Dheda K. Extensively drug-resistant Mycobacterium tuberculosis: what are
these bugs up to in India? Indian J Med Res. 2009 Oct;130(4):357-8. PubMed PMID:
19942736. |
| Schaaf HS, Moll AP, Dheda K. Multidrug- and extensively drug-resistant
tuberculosis in Africa and South America: epidemiology, diagnosis and management
in adults and children. Clin Chest Med. 2009 Dec;30(4):667-83, vii-viii. Review.
PubMed PMID: 19925960. |
| Patel VB, Bhigjee AI, Paruk HF, Singh R, Meldau R, Connolly C, Ndung'u T,
Dheda K. Utility of a novel lipoarabinomannan assay for the diagnosis of
tuberculous meningitis in a resource-poor high-HIV prevalence setting.
Cerebrospinal Fluid Res. 2009 Nov 2;6:13. PubMed PMID: 19878608; PubMed Central
PMCID: PMC2777116. |
| Kalsdorf B, Scriba TJ, Wood K, Day CL, Dheda K, Dawson R, Hanekom WA, Lange
C, Wilkinson RJ. HIV-1 infection impairs the bronchoalveolar T-cell response to
mycobacteria. Am J Respir Crit Care Med. 2009 Dec 15;180(12):1262-70. Epub 2009
Sep 24. PubMed PMID: 19797156; PubMed Central PMCID: PMC2796736. |
| Sohn H, Minion J, Albert H, Dheda K, Pai M. TB diagnostic tests: how do we figure out their costs? Expert Rev Anti Infect Ther. 2009 Aug;7(6):723-33. PubMed
PMID: 19681700. |
| Dheda K, van Zyl-Smit RN, Meldau R, Meldau S, Symons G, Khalfey H, Govender N, Rosu V, Sechi LA, Maredza A, Semple PL, Whitelaw A, Wainright H, Badri M, Dawson R, Bateman ED, Zumla A. Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis. Thorax. 2009 Jul 9. [Epub ahead of print] PubMed PMID: 19592392. |
| Dheda K, Smit RZ, Badri M, Pai M. T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs.
low-burden settings. Curr Opin Pulm Med. 2009 May;15(3):188-200. Review. PubMed
PMID: 19387262. |
| Marks DJ, Dheda K, Dawson R, Ainslie G, Miller RF. Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugs. Int J STD AIDS. 2009 May;20(5):339-45. PubMed PMID: 19386972. |
| Dheda K, van Zyl-Smit RN, Sechi LA, Badri M, Meldau R, Meldau S, Symons G, Semple L, Maredza A, Dawson R, Wainright H, Whitelaw A, Vallie Y, Raubenheimer P, Bateman ED, Zumla A. Utility of quantitative T cell responses versus unstimulated IFN-{gamma} for the diagnosis of pleural tuberculosis. Eur Respir J. 2009 Apr 22.
[Epub ahead of print] PubMed PMID: 19386693. |
| van Zyl-Smit RN, Pai M, Peprah K, Meldau R, Kieck J, Juritz J, Badri M, Zumla A, Sechi LA, Bateman ED, Dheda K. Within-subject variability and boosting of T-cell interferon-gamma responses after tuberculin skin testing. Am J Respir Crit Care Med. 2009 Jul 1;180(1):49-58. Epub 2009 Apr 2. PubMed PMID: 19342414. |
| Dheda K, Van-Zyl Smit RN, Sechi LA, Badri M, Meldau R, Symons G, Khalfey H, Carr I, Maredza A, Dawson R, Wainright H, Whitelaw A, Bateman ED, Zumla A.
Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting. PLoS One.
2009;4(3):e4689. Epub 2009 Mar 11. PubMed PMID: 19277111; PubMed Central PMCID:
PMC2650091. |
| Dhasmana DJ, Dheda K, Ravn P, Wilkinson RJ, Meintjes G. Immune Reconstitution Inflammatory Syndrome in HIV-Infected Patients Receiving Antiretroviral Therapy : Pathogenesis, Clinical Manifestations and Management. Drugs. 2008; 68:191-208. |
Dheda K, Chang J-S, Lala S, Huggett JF, Zumla A, Rook GAW. Gene expression of IL-17 and IL-23 in the lungs of patients with active tuberculosis, Thorax, 2008, in press.
Several manuscripts in submitted or in preparation: validation of x-ray scoring in TB, lung apoptosis markers in TB, oxygen tensions in asthma, adverse drug reactions |
| Trajman A, Pai M Dheda K, van Zyl Smit RN, Zwerling AA, Joshi R , Kalantri S, Daley P, Menzies D, Novel tests for diagnosing tuberculous pleural effusion: what works and what does not? ERJ 2008; 31: 1098-1106 |
| Dheda K, Shean K, Badri M. Extensively drug-resistant tuberculosis. N Engl J Med. 2008 Nov 27;359(22):2390; author reply 2391. PubMed PMID: 19038886. |
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